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KMID : 1197720110040010038
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대한파킨슨병 및 이상운동질환 학회지
2011 Volume.4 No. 1 p.38 ~ p.40
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The Sequence Effect in De Novo Parkinson’s Disease
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Kang Suk-Yun
Wasaka Toshiaki
Shamim Ejaz A.
Auh Sung-Young
Ueki Yoshino
Dang Nguyet
Hallett Mark
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Abstract
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Background and Purpose: The sequence effect (SE) in Parkinson’s disease (PD) denotes progressive slowness in speed or progressive decrease in amplitude of repetitive movements. It is a well-known feature of bradykinesia and is considered unique in PD. Until now, it was well-documented in advanced PD, but not in drug-naive PD. The aim of this study is to know whether the SE can also be measured in drug-naive PD.
Methods: We measured the SE with a computer-based, modified Purdue pegboard in 4 drug-naive PD patients, which matched our previous study with advanced PD patients.
Results: We observed progressive slowness during movement, that is, SE. Statistical analysis showed a strong statistical trend toward the SE with the right hand, but no significance with the left hand. There was no statistical significance of SE with either the more or less affected hands.
Conclusions: These results indicate that the SE can be identified in drug-naive PD, as well as in advanced PD, with objective measurements and support the idea that the SE is a feature in PD observed during the early stage of the disease without medication.
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KEYWORD
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Parkinson’s disease, De nove, Bradykinesia, Sequence effect, Progressive slowness, Pegboard test
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